From: Potential causes of subfertility in patients with intramural fibroids
Benign leiomyoma subtype | Microscopic findings |
---|---|
Benign leiomyoma | Findings include fascicles of spindle cells mixed with varying levels of collagen. Large blood vessels are present, and there is mild to absent cellular atypia and mitosis [58]. |
Mitotically active leiomyoma | Fibroid findings include necrosis, hemorrhage, vascular intrusion. Contains 5–9 mitotic figures (MF) per 10 high power fields (HPF) with no atypia [59]. |
Leiomyomas with bizarre nuclei (LBNs) | Microscopically, LBNs have the presence of aytipical pleomorphic nuclei. They may have high cellularity, and contain 2–7 MF/10HPFs [60]. |
Hydropic leiomyoma | These fibroids have focal collections of edema-like fluid and show hyaline degeneration [61]. |
Myxoid leiomyoma | Findings include large collections of acellular myxoid matrix, rich in acid mucins. They demonstrate a low mitotic rate (<2 MF/10 HPFs) [58]. |
Epitheloid leiomyoma | These benign leiomyomas have at least 50Â % of cells as epitheloid, but demonstrate a low mitotic rate (<3MFs/10HPFs) [58]. |