Table 1 Absolute and relative contraindications of treatment of EP with MTX
From: Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review
| Absolute Contraindications | Relative Contraindications |
|---|---|
| Clinical instability or significant pain suggestive of ruptured EP | Presence of fetal cardiac activity |
| Heterotopic pregnancy with viable and desired IUP | β-hCG level over 5000 mIU/mL |
| Liver function tests more than 2 times the upper limit of normal | An ectopic mass size greater than 4 cm in largest dimension |
| White blood cell count of <1500/uL | Patient refusal of blood transfusion |
| Platelet count <100,000/uL | Patient inability to follow up |
| Creatinine ≥1.5 mg/dL | |
| Current breastfeeding | |
| Active pulmonary disease | |
| Active peptic ulcer disease | |
| Moderate to severe anemia | |
| Sensitivity to methotrexate |