Table 1 Absolute and relative contraindications of treatment of EP with MTX

Clinical instability or significant pain suggestive of ruptured EP

Presence of fetal cardiac activity

Heterotopic pregnancy with viable and desired IUP

β-hCG level over 5000 mIU/mL

Liver function tests more than 2 times the upper limit of normal

An ectopic mass size greater than 4 cm in largest dimension

White blood cell count of <1500/uL

Patient refusal of blood transfusion

Platelet count <100,000/uL

Patient inability to follow up

Creatinine ≥1.5 mg/dL

Current breastfeeding

Active pulmonary disease

Active peptic ulcer disease

Moderate to severe anemia

Sensitivity to methotrexate