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Table 2 Single dose methotrexate (MTX) for treatment of ectopic pregnancy

From: Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review


Day 1

Day 4

Day 7


1. β-hCG


1. β-hCG

2. Safety labs (complete blood count, BUN, creatinine, AST, ALT)

2. Safety labs

3. Blood type and antibody screen


Give MTX (50 mg/m2 of body surface area IM)

no action

β-hCG decline <15 % from Day 4 to Day 7: MTX, return to day 1 of protocol. Repeat MTX up to a total of 4 doses

β-hCG decline >15 %: Check β-hCG at 1 week intervals until zero.