Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review

Table 4 Multiple dose methotrexate (MTX) and leucovorin (LEU) for treatment of ectopic pregnancy

	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 7	Day 8
Labs	1. β-hCG		β-hCG		β-hCG		β-hCG
	2. Safety labs (complete blood count, BUN, creatinine, AST, ALT)
	3. Blood type and antibody screen
Action	MTX (1 mg/kg, IM)	LEU (0.1 mg/kg, IM)	β-hCG decline <15 % from Day 1 to Day 3: Give MTX	LEU	β-hCG decline <15 % from Day 3 to Day 5: Give MTX	LEU	β-hCG decline <15 % from Day 5 to Day 7: Give MTX	LEU
Action	MTX (1 mg/kg, IM)	LEU (0.1 mg/kg, IM)	β-hCG decline >15 % from Day 1 to Day 3: Check β-hCG at one week intervals until zero.		β-hCG decline >15 % from Day 3 to Day 5: Check β-hCG at one week intervals until zero.		β-hCG decline >15 % from Day 5 to Day 7: Check β-hCG at one week intervals until zero.

ISSN: 2054-7099