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Table 4 Studies of PCOS and breast cancer risk

From: Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review

Author Year Study design Breast Cancer Cases (n) Overall result RR (95% CI)
Gottschau 2015 Registry Cohort (Danish) 59 1.1 (0.8–1.4)a
Shen 2015 Registry Cohort (Taiwan) 44 1.6 (0.9–2.8)a
Barryb 2014 Meta-analysis 3618 1.0 (0.6–1.4)a
Ghasemi 2010 Case–control (Iran) 166 0.7 (0.3–1.5)a
Brintonc 2010 Cohort (US) 89 1.3 (1.1–1.6)a
Terryd 2006 Cohort (US) 2267 0.8 (0.6–1.0)
Wild 2000 Cohort (UK) 49 1.3 (0.6–2.8)
Anderson 1997 Cohort (US) 883 1.2 (0.7–2)
Talamini 1997 Case–control (Italy) 2569 0.9 (0.4–1.8)
Gammon 1991 Case–control (US) 4730 0.47 (0.3–0.9)a
Coulame 1983 Cohort (US) 12 1.5 (0.8–2.6)
  1. a Effect estimate not adjusted for BMI
  2. b This meta-analysis includes the studies by Ghasemi, Anderson, and Talamini
  3. c In this study, androgen excess or menstrual disorders was evaluated rather than PCOS
  4. d In this study, infertility due to ovulatory disorders was evaluated rather than PCOS
  5. e In this study, chronic anovulation syndrome was evaluated rather than PCOS