Table 3 Ovarian stimulation cycle outcomes among women without cancer and women with local or systemic cancer

Woman’s Age at Stimulation (years)

34.6 ± 4.2

33.6 ± 4.8

27.1 ± 6.4

Baseline AFC (n)¹

9.4 ± 7.2

10.1 ± 7.4

7.3 ± 7.5

1.00 (Ref)

1.03 (0.89,1.21)

0.58 (0.41,0.83)*

1.00 (Ref)

0.64 (0.42,0.97)*

Starting FSH dose (IU)²

289.0 ± 121.3

354.2 ± 170.6

417.8 ± 180.7

0.00 (Ref)

80.9 (58.2103.6)*

252.4 (215.8289.1)*

0.00 (Ref)

158.80 (95.7221.9)*

Total FSH dose (IU)²

1839.2 ± 1294.7

2813.6 ± 1785.6

3358.9 ± 2147.3

0.00 (Ref)

1094.0 (825.9,1362.1)*

2483.0 (2050.8,2915.2)*

0.00 (Ref)

1124.82 (380.5,1869.2)*

Duration of stimulation (days)¹

11.7 ± 2.0

11.7 ± 2.3

12.2 ± 2.2

1.00 (Ref)

1.00 (0.96,1.04)

1.06 (0.99,1.14)

1.00 (Ref)

1.03 (0.94,1.12)

Total follicle number at hCG trigger (n)¹

12.9 ± 6.6

12.2 ± 8.4

13.2 ± 5.90

1.00 (Ref)

0.94 (0.85,1.04)

0.81 (0.68,0.96)*

1.00 (Ref)

0.91 (0.75–1.12)

Number of oocytes retrieved (n)¹

15.7 ± 8.6

16.8 ± 13.6

20.6 ± 21.0

1.00 (Ref)

1.04 (0.89,1.21)

1.03 (0.68,1.55)

1.00 (Ref)

1.05 (0.60,1.86)

Number of mature oocytes retrieved (n)¹

12.0 ± 7.1

12.2 ± 8.4

16.0 ± 14.8

1.00 (Ref)

0.99 (0.86,1.13)

1.02 (0.70,1.50)

1.00 (Ref)

1.12 (0.68,1.84)

Proportion of mature oocytes (n/n)¹

0.76 ± 0.19

0.76 ± 0.20

0.78 ± 0.15

1.00 (Ref)

0.96 (0.81,1.14)

0.93 (0.60,1.42)

1.00 (Ref)

0.94 (0.57,1.52)

Oocytes/AFC ratio (n/n)¹

2.28 ± 2.87

2.06 ± 2.11

3.92 ± 7.35

1.00 (Ref)

0.93 (0.67,1.28)

2.29 (1.01,5.23)*

1.00 (Ref)

2.15 (0.86,5.40)

Mature oocytes/AFC ratio (n/n)¹

1.76 ± 2.33

1.56 ± 1.59

2.82 ± 4.97

1.00 (Ref)

0.90 (0.65,1.25)

2.09 (0.94,4.65)

1.00 (Ref)

2.01 (0.81,4.99)

Number of embryos (n)³

8.9 ± 6.3

8.8 ± 6.4

12.3 ± 11.7

1.00 (Ref)

0.93 (0.85,1.03)

1.03 (0.88,1.19)

1.00 (Ref)

1.16 (0.98,1.39)

Cycle Cancelled [n (%)]⁴

14 ± 2.1

2 ± 1.9

9 ± 21.4

1.00 (Ref)

0.92 (0.21,4.11)

14.41 (4.83,42.98)*

1.00 (Ref)

17.03 (2.94,98.71)*