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Table 3 Ovarian stimulation cycle outcomes among women without cancer and women with local or systemic cancer

From: Responses to fertility treatment among patients with cancer: a retrospective cohort study

Cycle characteristic No Cancer (n = 664) Local Cancer (n = 105) Systemic Cancer (n = 42)
Woman’s Age at Stimulation (years) 34.6 ± 4.2 33.6 ± 4.8 27.1 ± 6.4
Baseline AFC (n)1 9.4 ± 7.2 10.1 ± 7.4 7.3 ± 7.5
1.00 (Ref) 1.03 (0.89,1.21) 0.58 (0.41,0.83)*
  1.00 (Ref) 0.64 (0.42,0.97)*
Starting FSH dose (IU)2 289.0 ± 121.3 354.2 ± 170.6 417.8 ± 180.7
0.00 (Ref) 80.9 (58.2103.6)* 252.4 (215.8289.1)*
  0.00 (Ref) 158.80 (95.7221.9)*
Total FSH dose (IU)2 1839.2 ± 1294.7 2813.6 ± 1785.6 3358.9 ± 2147.3
0.00 (Ref) 1094.0 (825.9,1362.1)* 2483.0 (2050.8,2915.2)*
  0.00 (Ref) 1124.82 (380.5,1869.2)*
Duration of stimulation (days)1 11.7 ± 2.0 11.7 ± 2.3 12.2 ± 2.2
1.00 (Ref) 1.00 (0.96,1.04) 1.06 (0.99,1.14)
  1.00 (Ref) 1.03 (0.94,1.12)
Total follicle number at hCG trigger (n)1 12.9 ± 6.6 12.2 ± 8.4 13.2 ± 5.90
1.00 (Ref) 0.94 (0.85,1.04) 0.81 (0.68,0.96)*
  1.00 (Ref) 0.91 (0.75–1.12)
Number of oocytes retrieved (n)1 15.7 ± 8.6 16.8 ± 13.6 20.6 ± 21.0
1.00 (Ref) 1.04 (0.89,1.21) 1.03 (0.68,1.55)
  1.00 (Ref) 1.05 (0.60,1.86)
Number of mature oocytes retrieved (n)1 12.0 ± 7.1 12.2 ± 8.4 16.0 ± 14.8
1.00 (Ref) 0.99 (0.86,1.13) 1.02 (0.70,1.50)
  1.00 (Ref) 1.12 (0.68,1.84)
Proportion of mature oocytes (n/n)1 0.76 ± 0.19 0.76 ± 0.20 0.78 ± 0.15
1.00 (Ref) 0.96 (0.81,1.14) 0.93 (0.60,1.42)
  1.00 (Ref) 0.94 (0.57,1.52)
Oocytes/AFC ratio (n/n)1 2.28 ± 2.87 2.06 ± 2.11 3.92 ± 7.35
1.00 (Ref) 0.93 (0.67,1.28) 2.29 (1.01,5.23)*
  1.00 (Ref) 2.15 (0.86,5.40)
Mature oocytes/AFC ratio (n/n)1 1.76 ± 2.33 1.56 ± 1.59 2.82 ± 4.97
1.00 (Ref) 0.90 (0.65,1.25) 2.09 (0.94,4.65)
  1.00 (Ref) 2.01 (0.81,4.99)
Number of embryos (n)3 8.9 ± 6.3 8.8 ± 6.4 12.3 ± 11.7
1.00 (Ref) 0.93 (0.85,1.03) 1.03 (0.88,1.19)
  1.00 (Ref) 1.16 (0.98,1.39)
Cycle Cancelled [n (%)]4 14 ± 2.1 2 ± 1.9 9 ± 21.4
1.00 (Ref) 0.92 (0.21,4.11) 14.41 (4.83,42.98)*
  1.00 (Ref) 17.03 (2.94,98.71)*
  1. All results reported as mean ± standard deviation, unless otherwise noted
  2. * indicates significance (p-value < 0.05)
  3. 1Poisson regression estimate, RR (95% CI), Adjusted for age and BMI at cycle start
  4. 2Linear regression estimate, β (95% CI), Adjusted for age and BMI at cycle start
  5. 3Poisson regression estimate, β (95% CI), Adjusted for age and BMI at cycle start, and ICSI use
  6. 4Logistic regression estimate, OR (95% CI), Adjusted for age and BMI at cycle start