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Table 4 Cycle outcomes among women with no cancer, breast cancer +/− BRCA mutations, or other cancer

From: Responses to fertility treatment among patients with cancer: a retrospective cohort study

Cycle characteristics No Cancer (n = 664) BRCA- Breast Cancer (n = 49) BRCA+ Breast Cancer (n = 13) Other Cancer (n = 68)
Woman’s Age at Stimulation (years) 34.6 ± 4.2 34.7 ± 3.7 32.3 ± 4.0 28.5 ± 6.4
Baseline AFC (n)1 9.4 ± 7.2 11.5 ± 7.7 7.7 ± 6.3 8.3 ± 7.8
1.00 (Ref) 1.22 (0.99,1.50) 0.76 (0.50,1.15) 0.70 (0.54,0.90)*
Starting FSH dose (IU)2 289.0 ± 121.3 342.0 ± 159.6 395.2 ± 236.5 375.5 ± 174.5
0.0 (Ref) 53.5 (21.1,85.9)* 142.8 (81.5204.1)* 183.2 (153.3213.1)*
Total FSH dose (IU)2 1839.2 ± 1294.7 2498.0 ± 1570.9 4326.9 ± 3046.6 2994.5 ± 1715.8
0.00 (Ref) 637.7 (302.4,1044.9)* 2775.0 (2072.0,3478.0)* 1916.5 (1573.7,2259.4)*
Duration of stimulation (days)1 11.7 ± 2.0 11.3 ± 2.4 13.0 ± 3.0 12.1 ± 2.0
1.00 (Ref) 0.96 (0.91,1.02) 1.12 (0.98,1.28) 1.05 (1.00,1.10)*
Total follicle number at hCG trigger (n)1 12.9 ± 6.6 12.1 ± 5.8 12.1 ± 5.5 13.3 ± 5.9
1.00 (Ref) 0.95 (0.83,1.09) 0.87 (0.68,1.12) 0.85 (0.75,0.97)*
Number of oocytes retrieved (n)1 15.7 ± 8.6 14.9 ± 9.6 15.5 ± 7.1 20.8 ± 19.7
1.00 (Ref) 0.94 (0.78,1.12) 0.86 (0.67,1.12) 1.11 (0.84,1.45)
Number of mature oocytes retrieved (n)1 12.0 ± 7.1 10.2 ± 5.9 11.5 ± 5.6 15.7 ± 12.4
1.00 (Ref) 0.85 (0.72,0.99)* 0.90 (0.69,1.16) 1.08 (0.85,1.38)
Proportion of mature oocytes (n/n)1 0.76 ± 0.19 0.78 ± 0.21 0.79 ± 0.07 0.80 ± 0.16
1.00 (Ref) 0.97 (0.78,1.19) 1.23 (0.94,1.60) 0.94 (0.69,1.26)
Oocytes/AFC ratio (n/n)1 2.28 ± 2.87 1.85 ± 2.15 2.29 ± 1.25 3.19 ± 5.71
1.00 (Ref) 0.73 (0.46,1.18) 1.37 (0.66,2.82) 1.69 (0.95,2.98)
Mature oocytes/AFC ratio (n/n)1 1.76 ± 2.33 1.29 ± 1.43 1.77 ± 0.94 2.39 ± 3.93
1.00 (Ref) 0.66 (0.41,1.06) 1.37 (0.66,2.80) 1.62 (0.94,2.80)
Number of embryos (n)3 8.9 ± 6.3 8.0 ± 10.0 6.4 ± 5.7 6.2 ± 6.7
1.00 (Ref) 0.84 (0.74,0.97)* 0.90 (0.67,1.21) 1.09 (0.98,1.23)
Cycle cancelled [n (%)]4 14 (2.1) 0 (0) 2 (15.4) 8 (11.8)
1.00 (Ref) 8.55 (1.70,42.88)* 6.06 (2.12,17.35)*
  1. All results reported as mean ± standard deviation, unless otherwise noted
  2. * indicates statistical significance (p-value < 0.05)
  3. 1Poisson regression estimate, RR (95% CI), Adjusted for age and BMI at cycle start
  4. 2Linear regression estimate, β (95% CI), Adjusted for age and BMI at cycle start
  5. 3Poisson regression estimate, β (95% CI), Adjusted for age and BMI at cycle start, and ICSI use
  6. 4Logistic regression estimate, OR (95% CI), Adjusted for age and BMI at cycle start