Table 4 Cycle outcomes among women with no cancer, breast cancer +/− BRCA mutations, or other cancer

Woman’s Age at Stimulation (years)

34.6 ± 4.2

34.7 ± 3.7

32.3 ± 4.0

28.5 ± 6.4

Baseline AFC (n)¹

9.4 ± 7.2

11.5 ± 7.7

7.7 ± 6.3

8.3 ± 7.8

1.00 (Ref)

1.22 (0.99,1.50)

0.76 (0.50,1.15)

0.70 (0.54,0.90)*

Starting FSH dose (IU)²

289.0 ± 121.3

342.0 ± 159.6

395.2 ± 236.5

375.5 ± 174.5

0.0 (Ref)

53.5 (21.1,85.9)*

142.8 (81.5204.1)*

183.2 (153.3213.1)*

Total FSH dose (IU)²

1839.2 ± 1294.7

2498.0 ± 1570.9

4326.9 ± 3046.6

2994.5 ± 1715.8

0.00 (Ref)

637.7 (302.4,1044.9)*

2775.0 (2072.0,3478.0)*

1916.5 (1573.7,2259.4)*

Duration of stimulation (days)¹

11.7 ± 2.0

11.3 ± 2.4

13.0 ± 3.0

12.1 ± 2.0

1.00 (Ref)

0.96 (0.91,1.02)

1.12 (0.98,1.28)

1.05 (1.00,1.10)*

Total follicle number at hCG trigger (n)¹

12.9 ± 6.6

12.1 ± 5.8

12.1 ± 5.5

13.3 ± 5.9

1.00 (Ref)

0.95 (0.83,1.09)

0.87 (0.68,1.12)

0.85 (0.75,0.97)*

Number of oocytes retrieved (n)¹

15.7 ± 8.6

14.9 ± 9.6

15.5 ± 7.1

20.8 ± 19.7

1.00 (Ref)

0.94 (0.78,1.12)

0.86 (0.67,1.12)

1.11 (0.84,1.45)

Number of mature oocytes retrieved (n)¹

12.0 ± 7.1

10.2 ± 5.9

11.5 ± 5.6

15.7 ± 12.4

1.00 (Ref)

0.85 (0.72,0.99)*

0.90 (0.69,1.16)

1.08 (0.85,1.38)

Proportion of mature oocytes (n/n)¹

0.76 ± 0.19

0.78 ± 0.21

0.79 ± 0.07

0.80 ± 0.16

1.00 (Ref)

0.97 (0.78,1.19)

1.23 (0.94,1.60)

0.94 (0.69,1.26)

Oocytes/AFC ratio (n/n)¹

2.28 ± 2.87

1.85 ± 2.15

2.29 ± 1.25

3.19 ± 5.71

1.00 (Ref)

0.73 (0.46,1.18)

1.37 (0.66,2.82)

1.69 (0.95,2.98)

Mature oocytes/AFC ratio (n/n)¹

1.76 ± 2.33

1.29 ± 1.43

1.77 ± 0.94

2.39 ± 3.93

1.00 (Ref)

0.66 (0.41,1.06)

1.37 (0.66,2.80)

1.62 (0.94,2.80)

Number of embryos (n)³

8.9 ± 6.3

8.0 ± 10.0

6.4 ± 5.7

6.2 ± 6.7

1.00 (Ref)

0.84 (0.74,0.97)*

0.90 (0.67,1.21)

1.09 (0.98,1.23)

Cycle cancelled [n (%)]⁴

14 (2.1)

0 (0)

2 (15.4)

8 (11.8)

1.00 (Ref)

–

8.55 (1.70,42.88)*

6.06 (2.12,17.35)*