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Table 3 Pre- and post-treatment outcomes stratified by patient aetiology

From: ART implantation failure and miscarriage in patients with elevated intracellular cytokine ratios: response to immune support therapy

 

n

Control Outcomes (Pre)

Intervention Outcomes (Post)

Sig (P)

Pregnancies

Miscarriages (MR%)

Pregnancies

Miscarriages (MR%)

 

RIF

56

0

0 (NA)

44

16 (36.4)

0.015

RPL

46

148

137 (92.6)

33

13 (39.4)

< 0.0001

- RM2

25

55

51 (92.7)

17

6 (35.3)

< 0.0001

- RM3+

19

87

82 (94.3)

15

7 (46.7)

< 0.0001

Other

32

32

23 (71.9)

26

15 (57.7)

0.50

Total

134

180

160 (89.0)

103

44 (42.7)

< 0.0001

  1. Population outcomes in the study population (n = 134) both before (Control outcomes) and after (intervention outcomes) immunomodulation, stratified by patient aetiology. RIF patients presented with repeated implantation failure (no pregnancy following at least 2 transfers of good quality embryos). RPL are patients with recurrent pregnancy loss, the RM2 and RM3+ subgroups refer to either 2 or ≥ 3 consecutive losses, while the remainder are non-consecutive losses. “Other” refers to secondary infertility patients with features of RIF/RPL, not meeting the strict criteria for either group. Significance calculated using McNemar’s test