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Table 1 Characteristics of the analyzed studies on endometrial transcriptomics for fertile women in natural and stimulated cycle

From: 15 years of transcriptomic analysis on endometrial receptivity: what have we learnt?

First author and reference Participants population N of patients Age Comparative Region Array First sample (day, n) Second sample (day, n) N of genes up-regulated N of genes down regulated
Fertile women
 Natural cycles
  Carson et al. [22] Fertile volunteers 6 Not specified ES vs MS North America HG U95A (Affymetrix) LH + 2/4 (n = 3) LH + 7/9 (n = 3) 323 370
  Riesewijk et al. [28] Fertile volunteers 10 23-39 ES vs MS Europe HG U95A (Affymetrix) LH + 2 (n = 5) LH + 7 (n = 5) 153 58
  Mirkin et al. [26] Fertile Oocyte donor 8 24–32 ES vs MS North America HG U95A v2 (Affymetrix) LH +3 (n = 3) LH +8 (n = 5) 49 58
  Talbi et al. [37] Normo-Ovulatory Women 28 23-50 ES vs MS North America HGU133 plus 2.0 (Affymetrix) ES
n = 3
MS
n = 8
1415 1463
  Haouzi et al. [1] normoresponder patients 31 22-36 ES vs MS Europe HGU133 plus 2.0 (Affymetrix) LH+2
n = 31
LH+7
n = 31
746 51
  Allegra et al. [38] patients who became pregnant 15 <35 Pregnant vs non- pregnant Europe Low Density Array technology LH+7/9
n = 15
23 11
  Van Vaerenbergh [40] patient who became pregnant 1 24 MS vs pregnant Europe HGU133 plus 2.0 (Affymetrix) LH+5/7
n = 1
4 -
  Diaz-Gimeno et al. [20] Fertile donors 88 22-39 ES vs MS Europe Agilent Whole Human Genome Oligo Microarray LH+1/5 (n = 13) LH+7 (n = 5) 143 95
  Horcajadas et al. [24] Fertile Oocyte donor 10 23-39 NC vs COH Europe HG_U133A (Affymetrix) LH+2 (n = 5) LH+7 (n = 14) 874 505
 Stimulated cycles
  Mirkin et al. [27] Fertile Oocyte donor 15 24-32 Ag vs Atg vs NC North America HG U95A v2 (Affymetrix) LH+8 (n = 5) hCG+9 (n = 10)
(Ag=3, Atg=7)
24 7
  Horcajadas et al. [24] Fertile Oocyte donor 10 23-39 NC vs COH Europe HG_U133A (Affymetrix) LH+7 (n = 7) hCG+7 (n = 5) 281 277
  Simon et al. [29] Fertile Oocyte donor 31 18–35 Ag vs Atg vs NC Europe HG_U133A (Affymetrix ) LH+7 (n = 12) hCG+2/7 (n = 14) 132 193
  Horcajadas et al. [49] healthy fertile
cycling donors
49 23–39 NC vs CCOS Europe HG_U133A (Affymetrix ) LH+7 (n = 5) hCG+7 (n = 5) 69 73
  Koler et al. [41] Fertile Oocyte donor 8 31-38 NC vs CCOS Europe + North America HG_U133A (Affymetrix ) LH+5 hCG+2 142 98
  Haouzi et al. [23] Normo-Ovulatory Women 21 30.9+ 3.3 NS vs CCOS Europe HGU133 plus 2.0 (Affymetrix) hCG+2 (n = 21) hCG+5 (n = 21) 777 221
  Haouzi et al. [30] normal-responder patients 21 - Ag vs Atg vs NC Europe HGU133 plus 2.0 (Affymetrix LH+2 (n = 21) LH+2 (n = 21)   
Ag hCG+2 (n = 7) Ag hCG+5 (n = 7) 731 451
Atg hCG+2 (n = 14) Atg hCG+5 (n = 14) 634 210