Table 2 Characteristics of the analyzed studies on endometrial transcriptomics for infertile women in natural and stimulated Cycle
From: 15 years of transcriptomic analysis on endometrial receptivity: what have we learnt?
First author and reference | Participants population | N of patients | Age | Comparative | Region | Array | First sample (day, n) | Second sample (day, n) | N of genes up-regulated | N of genes down regulated |
|---|---|---|---|---|---|---|---|---|---|---|
Infertile women | ||||||||||
Natural cycles | ||||||||||
Koler et al. [41] | women with unexplained infertility + fertile women | 32 | 19-40 | Infertile vs fertile | Europe | Array-Ready Oligo SetTM for the Human Genome Version 3.0 (Operon) | cd21 Infertile women (n = 4) fertile women (n = 12 | 25 | 288 | |
Altmae et al. [31] | women with unexplained infertility | Infertile women (n = 4) Fertile women (n = 4) | 30.5+4.0 31.8+3.8 | Infertile vs fertile | Europe | Whole Human Genome Oligo Microarray (Agilent Technologies) | LH +7 Infertile women (n = 4) fertile women (n = 5) | 145 | 115 | |
Koot et al. [34] | women experiencing RIF | 115 | 26-39 | Infertile vs fertile | Europe | Human whole genome gene expression microarrays V2 (Agilent) | mid-luteal phase n = 115 | 303 genes predictive of RIF | 303 genes predictive of RIF | |
Stimulated cycles | ||||||||||
Liu et al. [25] | Infertile women with normal menstrual cycles | 47 | 26 -38 | NC vs CCOS | Hong Kong | HG_U133A (Affymetrix) | LH+7 n = 5 | hCG+7 n = 8 | 244 | 159 |
Ruiz-Alonso et al. [36] | Patients with repeated implantation failure | 110 | 23-51 | RIF vs controls pWOI/Pwoi delayed/pWOI advanced | Europe | homemade ERA | P+5 LH+7 | - | - | |
Altmae et al. [19] | Patients with repeated implantation failure | 15 | 30.2 ± 4.3 | Infertile vs fertile | Europe | Whole Human Genome Oligo Microarray (Agilent Technologies | LH+7 (n = 5) P+6 (n = 5) | 443 | 446 | |
Haouzi et al. [33] | Oocyte-donation recipient patients RIF patients | 39 | 31-50 | NC vs HRT hormone replacement therapy | Europe | HGU133 plus 2.0 (Affymetrix) | LH+7 (n = 7) P+5 (n = 7) | 1814 | 477 | |