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Table 3 Pregnancy Outcome of Patients in Surveillance vs Standard protocols & Change in Hormones vs No Change

From: Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates

 

Surveillance protocol (N = 524)

Standard protocol (N = 379)

aOR (95% CI)

p-value

Patients with change in hormones (N = 175)

Patients without change in hormones (N = 349)

aOR (95% CI)

p-value

Positive hCGa

366/524 (70%)

231/379 (61%)

1.6 (1.2, 2.2)

0.002

115/175 (66%)

251/349 (72%)

0.8 (0.5, 1.2)

0.3

Live birth

268 (51%)

149 (39%)

1.6 (1.2, 2.2)

0.001

83 (47%)

185 (53%)

0.8 (0.6, 1.2)

0.4

Spontaneous abortion

51 (10%)

38 (10%)

1.0 (0.7, 1.7)

0.9

13 (7%)

38 (11%)

0.6 (0.3, 1.2)

0.2

Therapeutic abortion

4 (0.8%)

2 (0.5%)

1.4 (0.2, 8.1)

0.7

1 (0.6%)

3 (0.9%)

0.7 (0.1, 7.4)

0.8

Stillborn (> 20 weeks)

2 (0.4%)

2 (0.5%)

0.9 (0.1, 6.6)

0.9

1 (0.6%)

1 (0.3%)

2.0 (0.1, 35.0)

0.6

Ectopic Pregnancy

1 (0.2%)

2 (0.5%)

0.5 (0.1, 6.2)

0.6

0 (0%)

1 (0.3%)

–

–

Biochemical Pregnancy

40 (7.6%)

38 (10%)

0.8 (0.5, 1.3)

0.4

17 (10%)

23 (7%)

1.7 (0.9, 3.4)

0.1

  1. All analyses were performed using logistic regression adjusted for age, BMI, number of embryos transferred and PGT
  2. a = Positive hCG represents summation of all pregnancy outcomes listed below this row