Table 1 Mandatory, major, and minor criteria of POEMS syndrome^a

Mandatory Criteria

(required for diagnosis)

♦ Peripheral polyneuropathy

♦ Monocolonal plasma cell disorder

Major Criteria

(one required for diagnosis)

♦ Osteosclerotic bone lesions

♦ Elevated VEGF levels

♦ Castleman disease (angiofollicular lymph node hyperplasia)

Minor Criteria

(one required for diagnosis)

♦ Endocrine abnormalities

 ○ Adrenal

 ○ Thyroid

 ○ Pituitary

 ○ Gonadal

 ○ Parathryoid

♦ Skin changes

 ○ Hyperpigmentation

 ○ Hypertrichosis

 ○ Glomeruloid hemangiomata

 ○ Plethora

 ○ Acrocyanosis

 ○ Flushing

 ○ While nails

♦ Organomegaly

 ○ Splenomegaly

 ○ Hepatomegaly

 ○ Lymphadenopathy

♦ Extravascular volume overload

 ○ Edema

 ○ Pleural Effusion

 ○ Ascites

♦ Thrombocytosis/polycythemia

♦ Papilledema