Table 1 Genotype and allele frequencies of TNF-α 238, 308 and 376 variants in RPL patient and control groups. Statistical significance was defined at the level of 5% (p < 0.05)
Total | RPL group | Control group | Patients versus Controls | ||
(N = 183) | (N = 94) | (N = 89) | OR | p-value | |
TNF-α − 238, n (%) | |||||
GG | 171 (93.44) | 86 (91.49) | 85 (95.51) | 1 | |
GA | 11 (6.01) | 7 (7.45) | 4 (4.49) | 1.73 | 0.396 |
AA | 1 (0.55) | 1 (1.06) | 0 (0) | ||
Allele, n (%) | X2 | p-value | |||
G | 353 (96.45) | 179 (95.21) | 174 (97.75) | 1.722 | 0.261 |
A | 13 (3.55) | 9 (4.79) | 4 (2.25) | ||
Total | RPL group | Control group | Patients versus Controls | ||
(N = 111) | (N = 62) | (N = 49) | OR | p-value | |
TNF-α − 308, n (%) | |||||
GG | 52 (46.85) | 27 (43.55) | 25 (51.02) | 1 | |
GA | 46 (41.44) | 28 (45.16) | 18 (36.73) | 1.44 | 0.374 |
AA | 13 (11.71) | 7 (11.29) | 6 (12.24) | 1.08 | 0.901 |
Allele, n (%) | X2 | p-value | |||
G | 150 (67.57) | 82 (66.13) | 68 (69.39) | 0.2653 | 0.607 |
A | 72 (32.43) | 42 (33.87) | 30 (30.61) | ||
Total | RPL group | Control group | |||
(N = 183) | (N = 94) | (N = 89) | |||
TNF-α − 376, n (%) | |||||
GG | 183 (100.00) | 94 (100.00) | 89 (100.00) | ||
Allele, n (%) | |||||
G | 366 (100.00) | 188 (100.00) | 178 (100.00) | ||