Table 3 Associations between TNF-α 238 and 308 variants and parity status. Demographic data for age and body mass index (BMI) are also included. Statistical significance was defined at the level of 5% (p < 0.05)
TNF-α − 238 | RPL group AA (n = 1) | Control group AA (n = 0) | RPL group GG (n = 86) | Control group GG (n = 85) | p-value | RPL group GA (n = 7) | Control group GA (n = 4) | p-value | |
Age (years), mean (sd) | 39.00 (−) | – | 32.75 (5.16) | 43.32 (14.64) | < 0.001 | 33.71 (4.86) | 53.75 (23.29) | 0.049 | |
Body mass index (kg/m2), mean (sd) | 27.01 (−) | – | 25.03 (5.08) | 25.37 (4.19) | 0.654 | 22.34 (1.95) | 28.69 (3.68) | 0.004 | |
Parity, n (%) | < 0.001 | 0.061 | |||||||
No | 1 (100.00) | – | 71 (100.00) | 0 (0.00) | 5 (100.00) | 0 (0.00) | |||
Yes | 0 (0.00) | – | 15 (15.00) | 85 (85.00) | 2 (33.33) | 4 (66.67) | |||
TNF-α − 308 | RPL group AA (n = 7) | Control group AA (n = 6) | p-value | RPL group GG (n = 27) | Control group GG (n = 25) | p-value | RPL group GA (n = 28) | Control group GA (n = 18) | p-value |
Age (years), mean (sd) | 31.29 (4.54) | 42.83 (14.69) | 0.073 | 33.19 (4.88) | 38.54 (10.58) | 0.022 | 34.67 (4.39) | 47.22 (15.75) | < 0.001 |
Body mass index (kg/m2), mean (sd) | 24.18 (6.33) | 25.10 (3.33) | 0.774 | 24.12 (4.09) | 24.85 (4.56) | 0.563 | 23.80 (4.03) | 27.24 (3.56) | 0.006 |
Parity, n (%) | 0.001 | < 0.001 | < 0.001 | ||||||
No | 7 (100.00) | 0 (0.00) | 23 (100.00) | 0 (0.00) | 21 (100.00) | 0 (0.00) | |||
Yes | 0 (0.00) | 6 (100.00) | 4 (13.79) | 25 (86.21) | 7 (28.00) | 18 (72.00) |