Low dose hCG supplementation in a Gn-RH-agonist trigger protocol is associated with worse pregnancy outcomes: a retrospective cohort study

Table 3 The association between trigger type and IVF outcomes.

	Trigger Type
	hCG trigger (ref) Mean (SD)	Dual trigger Mean (SD)	Adjusted RR^a (95% CI)
Oocytes retrieved	14.9 (7.2)	18.1 (8.1)	1.22 (1.15, 1.30)
Mature oocytes	11.5 (6.1)	13.5 (6.6)
Mature oocytes rate^b	0.78 (0.18)	0.75 (0.18)	0.98 (0.94, 1.01)
Normally fertilized embryos (2PN)	8.7 (5.2)	11.0 (6.1)
Fertilization rate^c	0.77 (0.23)	0.80 (0.20)	1.07 (1.03, 1.10)
Blastocysts^d	7.9 (4.0) n = 305	9.2 (4.7) n = 328
Blastocyst conversion rate^e	0.72 (0.21)	0.72 (0.20)	0.99 (0.95, 1.04)
OHSS	3 (0.6%)	0 (0%)
Number of embryos transferred	1.5 (0.6)	1.2 (0.5)	0.85 (0.81, 0.89)

^aModel adjusted for maternal age at retrieval, ovarian diagnosis and AMH. Tested covariates that did not show a significant association between the exposure and the outcome and thus were not included in the final model were race, BMI, day 3 FSH, use of ICSI, day of embryo transfer, endometrial thickness and number of embryos transferred.
^bMature oocyte rate defined as Mature oocytes/oocytes retrieved.
^cFertilization rate defined as 2PNs/oocytes retrieved.
^dOnly those with a day 5 transfer were included in the analysis.
^eBlastocyst conversion rate defined as blastocysts/2PNs.

ISSN: 2054-7099