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Fig. 2 | Fertility Research and Practice

Fig. 2

From: Onco-fertility and personalized testing for potential for loss of ovarian reserve in patients undergoing chemotherapy: proposed next steps for development of genetic testing to predict changes in ovarian reserve

Fig. 2

Proposed two-step screening algorithm to validate feasibility of genetic ovarian reserve testing in clinical practice. The flow chart demonstrates a cost-effective workflow to stratify patients into risk groups and facilitate evidence-based fertility preservation counseling. Step 1: FMR1 and BRCA1 mutation status are routinely tested in some clinics. FMR1 or BRCA 1 positive patients are at higher risk baseline. Step 2: Non-carriers of FMR 1 or BRCA 1 are triaged to undergo a 7-gene panel testing to further test for genetic variants to test their risk of loss of ovarian reserve after chemotherapy

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