Onco-fertility and personalized testing for potential for loss of ovarian reserve in patients undergoing chemotherapy: proposed next steps for development of genetic testing to predict changes in ovarian reserve

Table 1 Chemotherapeutic agents used in breast cancer treatment cause ovarian damage

Chemotherapeutic Agent	Biological Target	Mechanism of Ovarian Damage	Reference
Taxanes	microtubule	Apoptosis and suppression of follicle development	[25, 26]
Anthracyclines	DNA	Apoptosis, atresia and overactivation of ovarian follicles	[27, 28]
Platinum agents	DNA	Both apoptosis and overactivation of ovarian follicles	[29]
Vinorelbine	microtubule	Unknown or none	[30]
Capecitabine	DNA	Unknown or none	[31]
Gemcitabine	DNA	Apoptosis of pre-antral/antral follicles	[32]
Ixabepilone	microtubule	Unknown	N/A
Eribulin	microtubule	Unknown	N/A

ISSN: 2054-7099