Table 3 Two dose methotrexate (MTX) for treatment of ectopic pregnancy
From: Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review
| Â | Day 0 | Day 4 | Day 7 | Day 11 | Day 14 |
|---|---|---|---|---|---|
Labs | 1. β-hCG | β-hCG | 1. β-hCG | β-hCG | 1. β-hCG |
2. Safety labs (complete blood count, BUN, creatinine, AST, ALT) | 2. Safety labs | 2. Safety labs | |||
3. Blood type and antibody screen | |||||
Action | Give MTX (50 mg/m2 of body surface area IM) | Give MTX (50 mg/m2 of body surface area IM) | β-hCG decline <15 % from Day 4 to Day 7: Give MTX | β-hCG decline <15 % from Day 7 to Day 11: Give MTX | β-hCG decline <15 % from Day 11 to Day 14: Refer for surgery |
β-hCG decline >15 % from Day 4 to Day 7: Check β-hCG at 1 week intervals until zero. | β-hCG decline >15 % from Day 7 to Day 11: Check β-hCG at 1 week intervals until zero. | β-hCG decline >15 % from Day 11 to Day 14: Check β-hCG at 1 week intervals until zero. |