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Table 3 Two dose methotrexate (MTX) for treatment of ectopic pregnancy

From: Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review

  Day 0 Day 4 Day 7 Day 11 Day 14
Labs 1. β-hCG β-hCG 1. β-hCG β-hCG 1. β-hCG
2. Safety labs (complete blood count, BUN, creatinine, AST, ALT) 2. Safety labs 2. Safety labs
3. Blood type and antibody screen
Action Give MTX (50 mg/m2 of body surface area IM) Give MTX (50 mg/m2 of body surface area IM) β-hCG decline <15 % from Day 4 to Day 7: Give MTX β-hCG decline <15 % from Day 7 to Day 11: Give MTX β-hCG decline <15 % from Day 11 to Day 14: Refer for surgery
β-hCG decline >15 % from Day 4 to Day 7: Check β-hCG at 1 week intervals until zero. β-hCG decline >15 % from Day 7 to Day 11: Check β-hCG at 1 week intervals until zero. β-hCG decline >15 % from Day 11 to Day 14: Check β-hCG at 1 week intervals until zero.