Articles

Association of Tumor Necrosis Factor-α -308G>A, -238G>A and -376G>A polymorphisms with recurrent pregnancy loss risk in the Greek population

Promoter region SNPs in TNF-α have been studied in association with Recurrent Pregnancy Loss (RPL) occurrence in various populations. Among them, −238G > A, −308G > A and − 376G > A have been frequently invest...

Authors: Sofoklis Stavros, Despoina Mavrogianni, Myrto Papamentzelopoulou, Evaggelos Basamakis, Hend Khudeir, Alexandros Psarris and Peter Drakakis

MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity

Abnormalities in endometrial receptivity has been identified as a major barrier to successful embryo implantation. Endometrial receptivity refers to the conformational and biochemical changes occurring in the ...

Authors: Sadaf Zafir, Wei Zhou, Ellen Menkhorst, Leilani Santos and Evdokia Dimitriadis

Self-reported infertility diagnoses and treatment history approximately 20 years after fertility treatment initiation

Infertility history may have important implications for clinical practice and scientific discovery. Previous research on the validity of self-reported infertility measurements has been limited in scope and dur...

Authors: Alesia M. Jung, Stacey A. Missmer, Daniel W. Cramer, Elizabeth S. Ginsburg, Kathryn L. Terry, Allison F. Vitonis and Leslie V. Farland

The prevalence of depression symptoms among infertile women: a systematic review and meta-analysis

Infertile women’s mental health problems, including depression, are key fertility health issues that affect infertile women more severely than infertile men. Depression may threaten the health of individuals a...

Authors: Zahra Kiani, Masoumeh Simbar, Sepideh Hajian and Farid Zayeri

A rare case of extensive placenta accreta in twin pregnancy after GnRH agonist treatment of adenomyosis

Adenomyosis remains an enigma for the reproductive endocrinologist. It is thought to contribute to sub-fertility, and its only curative treatment is hysterectomy. However, studies have documented increased liv...

Authors: Shilpi Agrawala, Jeevitha Patil, Sukhkamal Campbell and Terri Lynn Woodard

The clinical relevance of luteal phase progesterone support in true natural cycle cryopreserved blastocyst stage embryo transfers: a retrospective cohort study

More than 67% of all embryos transferred in the United States involve frozen-thawed embryos. Progesterone supplementation is necessary in medicated cycles to luteinize the endometrium and prepare it for implan...

Authors: Ian N. Waldman, Catherine Racowsky, Emily R. Disler, Ann Thomas, Andrea Lanes and Mark D. Hornstein

Fertility education: what’s trending on Instagram

To determine the prevalence, authorship, and types of fertility-related information shared on Instagram targeted toward a new patient interested in fertility options using hashtag and content analysis. Seconda...

Authors: Alexandra Peyser, Liat Goldstein, Christine Mullin and Randi H. Goldman

Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles

To evaluate factors affecting oocyte/embryo quality in PolyCystic Ovary Syndrome (PCOS) patients undergoing Assisted Reproductive Technology (ART) cycles.

Authors: Roshan Nikbakht, Razieh Mohammadjafari, Mina Rajabalipour and Mahin Taheri Moghadam

The causes of infertility in women presenting to gynaecology clinics in Harare, Zimbabwe; a cross sectional study

Infertility affects 48.5 million couples globally. It is defined clinically as failure to conceive after 12 months or more of regular unprotected sexual intercourse. The contribution of various aetiological fa...

Authors: Mugove G. Madziyire, Thulani L. Magwali, Vasco Chikwasha and Tinovimba Mhlanga

Predictive factors for intrauterine insemination outcomes: a review

Intrauterine insemination (IUI) is a frequently utilized method of assisted reproduction for patients with mild male factor infertility, anovulation, endometriosis, and unexplained infertility. The purpose of ...

Authors: Anabel Starosta, Catherine E. Gordon and Mark D. Hornstein

A cross-sectional survey of fertility knowledge in obstetrics and gynecology residents

To evaluate fertility knowledge among current Obstetrics and Gynecology (OB-GYN) residents using a recently published validated instrument, the Fertility and Infertility Treatment Knowledge Score (FIT-KS).

Authors: Leah May Roberts, Rashmi Kudesia, Huaqing Zhao, Shaliz Dolan and Marisa Rose

Association of depression with sexual function in women with history of recurrent pregnancy Loss: descriptive-correlational study in Tehran, Iran

The present study aimed to investigate the relationship between depression and sexual function in women with recurrent pregnancy loss.

Authors: Seyed Ali Azin, Fahimeh Golbabaei, J. Catja Warmelink, Sadaf Eghtedari, Shima Haghani and Fahimeh Ranjbar

Primary and secondary infertility in Africa: systematic review with meta-analysis

Infertility is a practical concern of Africans due to social disgrace and exclusion. This meta-analysis aims to analyze the proportion of primary and secondary infertility and identify the etiologic factors ba...

Authors: Melese Shenkut Abebe, Mekbeb Afework and Yeshiwas Abaynew

Cognitive testing of a survey instrument for self-assessed menstrual cycle characteristics and androgen excess

In large population-based studies, there is a lack of existing survey instruments designed to ascertain menstrual cycle characteristics and androgen excess status including hirsutism, alopecia, and acne. Our o...

Authors: Shruthi Mahalingaiah, Carol Cosenza, J. Jojo Cheng, Erika Rodriguez and Ann Aschengrau

Oocyte cryopreservation in the setting of a vascular endothelial growth factor (VEGF)-producing paraneoplastic syndrome: a case report and review of literature

Many reproductive aged women with new oncologic diagnoses choose to undergo emergency oocyte or embryo cryopreservation prior to initiating potentially gonadal toxic oncologic therapies. Ovarian hyperstimulati...

Authors: Emily Spurlin and Paula Brady

Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature

Double ovarian stimulation (DuoStim) involves two rounds of controlled ovarian stimulation (COS) and oocyte retrieval in immediate succession. It represents a promising approach to increase oocyte yield for pa...

Authors: Laura C. Gemmell, Jason D. Wright and Paula C. Brady

Vaginal cuff dehiscence following transvaginal oocyte retrieval: a case report

Vaginal cuff dehiscence (VCD) is a rare but potentially serious complication following hysterectomy with an estimated incidence of 0.14–1.4%. There is a wide range of risk factors thought to contribute to VCD,...

Authors: Sarah K. O’Connor, David A. Ryley, Charles W. Obasiolu, Katharine M. Esselen, Christine C. Skiadas and Wendy Kuohung

Disparities in fertility knowledge among women from low and high resource settings presenting for fertility care in two United States metropolitan centers

Few studies have examined health literacy and fertility knowledge among women from low income, socio-culturally diverse communities presenting for fertility care in the United States. Our study sought to exami...

Authors: Jacquelyn R. Hoffman, Meaghan A. Delaney, Cecilia T. Valdes, Diana Herrera, Samuel L. Washington, Lusine Aghajanova, James F. Smith and Christopher N. Herndon

Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States

Azoospermia is present in 10% of men presenting with infertility and surgical sperm retrieval rates for men with azoospermia due to spermatogenic dysfunction remain low. We investigated the incidence of failed...

Authors: Alexandra Joice Berger, Valary Raup, Ramy Abou Ghayda, Andrea Lanes and Martin Kathrins

The continuum of ovarian response leading to BIRTH, a real world study of ART in Spain

The first biosimilar of recombinant follicle stimulating hormone (rFSH) launched in Europe was Bemfola® in 2014 following a clinical development programme demonstrating efficacy and safety to the satisfaction ...

Authors: Marcos Ferrando, Buenaventura Coroleu, Luis Rodríguez-Tabernero, Gorka Barrenetxea, Cristina Guix, Fernando Sánchez and Julian Jenkins

Risk profile of Qatari women treated for infertility in a tertiary hospital: a case-control study

Female infertility is a multifactorial condition constituting a worldwide public health problem. The ability to reproduce is an important product of any marriage, hence infertility may exert a negative impact ...

Authors: Sarah Musa and Sherif Osman

Fertility patients’ use and perceptions of online fertility educational material

Online educational information is highly sought out by patients with infertility. This study aims to assess patient-reported usage and helpfulness of fertility educational material on a clinic website and soci...

Authors: Claire Ann Jones, Chaula Mehta, Rhonda Zwingerman and Kimberly E. Liu

Intramuscular progesterone versus 8% Crinone vaginal gel for luteal phase support following blastocyst cryopreserved single embryo transfer: a retrospective cohort study

The optimal route of progesterone administration for luteal support in cryopreserved embryo transfer (CET) has been the subject of much debate. While most published research has pertained to day 3 transfers, r...

Authors: Jennifer B. Bakkensen, Catherine Racowsky, Ann M. Thomas, Andrea Lanes and Mark D. Hornstein

Attitudes among paediatric healthcare professionals in Sweden towards sperm donation to single women: a survey study

The number of families conceived through sperm donation to single women is increasing. However, there is limited knowledge about health care professionals’ attitudes towards solo-mothers by choice, and there i...

Authors: Gabriela Armuand, Agneta Skoog Svanberg, Claudia Lampic, Evangelia Elenis and Gunilla Sydsjö

Differentiating pregnancies near the uterotubal junction (angular, cornual, and interstitial): a review and recommendations

Eccentrically located intracavitary pregnancies, which include pregnancies traditionally termed as cornual and/or angular, have long presented complex diagnostic and management challenges given their inherent ...

Authors: Alex R. Finlinson, Kassie J. Bollig and Danny J. Schust

The prevalence of anxiety symptoms in infertile women: a systematic review and meta-analysis

Infertile women are exposed more frequently to anxiety risk than are infertile men, thereby adversely affecting the procedures with which they are treated and the quality of their lives. Yet, this problem is o...

Authors: Zahra Kiani, Masoumeh Simbar, Sepideh Hajian, Farid Zayeri, Maryam Shahidi, Marzieh Saei Ghare Naz and Vida Ghasemi

Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates

Given no consensus in the literature, this study sought to determine if a protocol of measuring serum estradiol and progesterone the day prior to frozen embryo transfer (FET) improves likelihood of pregnancy a...

Authors: Snigdha Alur-Gupta, Margaret Hopeman, Dara S. Berger, Kurt T. Barnhart, Suneeta Senapati and Clarisa Gracia

Staging of the estrous cycle and induction of estrus in experimental rodents: an update

Determination of the phases of the estrous cycle and induction of estrus (heat) in experimental animals remains useful, especially in reproductive function research.

Authors: Ayodeji Folorunsho Ajayi and Roland Eghoghosoa Akhigbe

Indicators of male fertility potential in adult patients with beta-thalassemia major: a comparative study between patients undergone allogeneic stem cell transplantation and transfusion-dependent patients

Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative treatment for thalassemia major (TM). Infertility and its indicators have been assessed in transfusion dependent ...

Authors: Tahereh Rostami, Mohammad Amir Mohammadifard, Shahla Ansari, Azadeh Kiumarsi, Nasrollah Maleki, Amir Kasaeian, Fatemeh Aghamahdi, Soroush Rad and Ardeshir Ghavamzadeh

Risk factors of tubal infertility in a tertiary hospital in a low-resource setting: a case-control study

Infertility is the inability to sustain a pregnancy in a woman with regular (2–3 times per week) unprotected sexual intercourse for a period of 1 year. This is a major public health problem that remains under-...

Authors: Thomas Obinchemti Egbe, Theophile Nana-Njamen, Felix Elong, Robert Tchounzou, Andre Gaetan Simo, Gaelle Padjip Nzeuga, Cedric Njamen Nana, Emmanuella Manka’a, Charlotte Tchente Nguefack and Gregory Edie Halle-Ekane

Should we transfer poor quality embryos?

To evaluate if it is safe and effective to transfer poor quality embryos.

Authors: Anastasia Kirillova, Sergey Lysenkov, Maria Farmakovskaya, Yulia Kiseleva, Bella Martazanova, Nona Mishieva, Aydar Abubakirov and Gennady Sukhikh

Public reporting of IVF outcomes influences medical decision-making and physician training

Since 1992 ART clinics have been required to report outcome data. Our objective was to assess practitioners’ opinions of the impact of public reporting of assisted reproductive technology (ART) outcomes on tre...

Authors: Stephanie Gunderson, Emily S. Jungheim, Caleb B. Kallen and Kenan Omurtag

Bayesian smoothed small-areas analysis of urban inequalities in fertility across 1999–2013

Since the 2008 economic crisis in Spain, overall fertility has continued to decrease, while urban inequalities have increased. There is a general lack of studies of fertility patterns in small-areas of Spanish...

Authors: Brenda Biaani León-Gómez, Mercè Gotsens, Marc Marí-Dell’Olmo, Ma. Felicitas Domínguez-Berjón, Miguel Ángel Luque-Fernandez, Unai Martin, Maica Rodríguez-Sanz and Gloria Pérez

Impact of genital Chlamydia trachomatis infection on reproductive outcomes among infertile women undergoing tubal flushing: a retrospective cohort at a fertility centre in Uganda

The impact of current C. trachomatis on clinical pregnancy and live birth rates among women undergoing tubal flushing is largely unknown. This study aimed to investigate whether current female genital C. trachoma...

Authors: Anthony Kayiira, Daniel Zaake, Michael Webba Lwetabe and Peter Sekweyama

IVF outcomes after hysteroscopic metroplasty in patients with T- shaped uterus

T- shaped uterus may be associated with infertility and adverse pregnancy outcomes. Hysteroscopic metroplasty may improve the reproductivity for these cases. To our knowledge, there is no data in literature ab...

Authors: Esra Uyar, Deniz Usal, Belgin Selam, Mehmet Cincik and Tayfun Bagis

Use and pattern of previous care received by infertile Nigerian women

Prevalence of infertility in sub-Saharan Africa is high yet fertility care, its development and access is limited in resource-poor countries like Nigeria so infertile women resort to different forms of treatme...

Authors: Amina Mohammed-Durosinlorun, Joel Adze, Stephen Bature, Amina Abubakar, Caleb Mohammed, Matthew Taingson and Lydia Airede

Data mining polycystic ovary morphology in electronic medical record ultrasound reports

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, oligo-anovulation, and numerous ovarian cysts. Hospital electronic medical records provide an avenue for investigating polycystic ovary m...

Authors: Jay Jojo Cheng and Shruthi Mahalingaiah

Association of Female Sexual Dysfunction and Fertility: a cross sectional study

Sexual function plays an essential role in the bio-psychosocial wellbeing and quality of life of women and disturbances in sexual functioning often result in significant distress. Female sexual dysfunction (FS...

Authors: Felix Mwembi Oindi, Alfred Murage, Valentino Manase Lema and Abraham Mwaniki Mukaindo

Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval

Vaginal cuff dehiscence is a rare complication of hysterectomy. Those who choose to undergo controlled ovarian stimulation (COS) and oocyte cryopreservation following hysterectomy must be aware that elevated a...

Authors: Alexandra Peyser, Avner Hershlag, Antoinette Sakaris and Tomer Singer

Number of motile spermatozoa inseminated and pregnancy outcomes in intrauterine insemination

To determine whether age modifies the effect of the number of motile spermatozoa inseminated (NMSI) as a predictor of success in Intrauterine Insemination (IUI).

Authors: Palma G. Gubert, Jessica Pudwell, Dean Van Vugt, Robert L. Reid and Maria P. Velez

15 years of transcriptomic analysis on endometrial receptivity: what have we learnt?

Authors: Soumaya Messaoudi, Imane EL Kasmi, Amelie Bourdiec, Kimberley Crespo, Laurence Bissonnette, Cecile Le Saint, François Bissonnette and Isaac-Jacques Kadoch

Case report of pelvic tuberculosis resulting in Asherman’s syndrome and infertility

Approximately one-third of the world’s population is infected with Mycobacterium tuberculosis, and it is a leading cause of infertility in endemic countries. The global incidence of tuberculosis (TB) is growing a...

Authors: Mary Louise Fowler and Shruthi Mahalingaiah

Epidemiology of infertility and characteristics of infertile couples requesting assisted reproduction in a low-resource setting in Africa, Sudan

Infertility is a big health problem worldwide. Few data exist on infertility in Sudan.

Authors: Osama G. Elhussein, Mohamed A. Ahmed, Suliman O. Suliman, leena I. Yahya and Ishag Adam

Perceptions, expectations and challenges among men during in vitro fertilization treatment in a low resource setting: a qualitative study

Partner support is very important in alleviating the burden of infertility related stress and although understudied, partner coping patterns also play a key role in the other partner’s ability to cope with the...

Authors: Daniel Zaake, Anthony Kayiira and Imelda Namagembe

Knowledge and attitudes regarding elective oocyte cryopreservation in undergraduate and medical students

To assess knowledge and attitudes regarding elective oocyte cryopreservation among female undergraduate students (UG) and medical students (MS) in Eastern Virginia.

Authors: Arnold M. Mahesan, Seifeldin Sadek, Hadi Ramadan, Silvina Bocca, Anthea B. M. Paul and Laurel Stadtmauer

Case report: interventional radiology’s potential role for in vitro fertilization post ovarian transposition and pelvic radiation

Ovarian transposition is a procedure that can help preserve fertility for female patients requiring radiation in the abdominopelvic region. However, the displacement of ovaries from its original anatomic locat...

Authors: Benjamin Jang, Aaron Rohr, Paras P. Vakharia, Zachary Collins, Courtney Marsh, Isabella Herrera and Thomas Fahrbach

Ethnic disparities in fertility and its determinants in Nigeria

High fertility rate has been consistently reported in Nigeria. The three major ethnic groups in Nigeria, Hausa/Fulani, Igbo, and Yoruba have different socio-cultural identities particularly those that relate t...

Authors: Ayo Stephen Adebowale

Antimullerian hormone is a predictor of live birth in patients with recurrent pregnancy loss

Ovarian reserve testing is not routinely performed in the evaluation of recurrent pregnancy loss (RPL). The objective of this study was to determine if AMH levels are predictive of live birth rate in RPL patie...

Authors: Gayathree Murugappan, Lora Shahine and Ruth B. Lathi

Congenital Zika syndrome arising from sexual transmission of Zika virus, a case report

Sexual transmission of Zika virus is well documented and pregnant women are advised to abstain or use barrier protection if a sexual partner has risk for Zika infection. However, to date there has not been a d...

Authors: Christina D. Yarrington, Davidson H. Hamer, Wendy Kuohung and Aviva Lee-Parritz

ART implantation failure and miscarriage in patients with elevated intracellular cytokine ratios: response to immune support therapy

The origins of adverse reproductive outcome can be multifactorial, but the contribution of the maternal immune system is considered debatable. Elevated intracellular cytokine ratios have been proposed, althoug...

Authors: Conor Harrity, Lyuda Shkrobot, David Walsh and Kevin Marron